AustralieFrV1, Main, Exploration, bibRecord, 003C71

MC1R variants increased the risk of sporadic cutaneous melanoma in darker-pigmented Caucasians: a pooled-analysis from the M-SKIP project

Identifieur interne : 003C71 ( Main/Exploration ); précédent : 003C70; suivant : 003C72

MC1R variants increased the risk of sporadic cutaneous melanoma in darker-pigmented Caucasians: a pooled-analysis from the M-SKIP project

Auteurs : Elena Pasquali [Italie] ; José C. García-Borr N [Espagne] ; Maria Concetta Fargnoli [Italie] ; Sara Gandini [Italie] ; Patrick Maisonneuve [Italie] ; Vincenzo Bagnardi [Italie] ; Claudia Specchia [Italie] ; Fan Liu [Pays-Bas] ; Manfred Kayser [Pays-Bas] ; Tamar Nijsten [Pays-Bas] ; Eduardo Nagore [Espagne] ; Rajiv Kumar [Allemagne] ; Johan Hansson [Suède] ; Peter A. Kanetsky [États-Unis] ; Paola Ghiorzo [Italie] ; Tadeusz Debniak [Pologne] ; Wojciech Branicki [Pologne] ; Nelleke A. Gruis [Pays-Bas] ; Jiali Han [États-Unis] ; Terry Dwyer [Australie] ; Leigh Blizzard [Australie] ; Maria Teresa Landi [États-Unis] ; Giuseppe Palmieri [Italie] ; Gloria Ribas [Espagne] ; Alexander Stratigos [Grèce] ; M. Laurin Council [États-Unis] ; Philippe Autier [France] ; Julian Little [Canada] ; Julia Newton-Bishop [Royaume-Uni] ; Francesco Sera [Royaume-Uni] ; Sara Raimondi [Italie]

Source :

International journal of cancer. Journal international du cancer [ 0020-7136 ] ; 2014.

RBID : PMC:4378685

Abstract

The MC1R gene is a key regulator of skin pigmentation. We aimed to evaluate the association between MC1R variants and the risk of sporadic cutaneous melanoma (CM) within the M-SKIP project, an international pooled-analysis on MC1R, skin cancer and phenotypic characteristics. Data included 5,160 cases and 12,119 controls from 17 studies. We calculated a Summary Odds Ratio (SOR) for the association of each of the nine most studied MC1R variants and of variants combined with CM by using random-effects models. Stratified analysis by phenotypic characteristics were also performed.

Melanoma risk increased with presence of any of the main MC1R variants: the SOR for each variant ranged from 1.47 (95%CI: 1.17–1.84) for V60L to 2.74 (1.53–4.89) for D84E. Carriers of any MC1R variant had a 66% higher risk of developing melanoma compared to wild-type subjects (SOR; 95%CI: 1.66; 1.41–1.96), and the risk attributable to MC1R variants was 28%. When taking into account phenotypic characteristics, we found that MC1R–associated melanoma risk increased only for darker-pigmented Caucasians: SOR (95%CI) was 3.14 (2.06–4.80) for subjects with no freckles, no red hair and skin type III/IV.

Our study documents the important role of all the main MC1R variants in sporadic CM and suggests that they have a direct effect on melanoma risk, independently on the phenotypic characteristics of carriers. This is of particular importance for assessing preventive strategies, which may be directed to darker-pigmented Caucasians with MC1R variants as well as to lightly-pigmented, fair-skinned subjects.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378685

DOI: 10.1002/ijc.29018
PubMed: 24917043
PubMed Central: 4378685

Affiliations:

Le document en format XML

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 variants increased the risk of sporadic cutaneous melanoma in darker-pigmented Caucasians: a pooled-analysis from the M-SKIP project</title>
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<author><name sortKey="Liu, Fan" sort="Liu, Fan" uniqKey="Liu F" first="Fan" last="Liu">Fan Liu</name>
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<author><name sortKey="Ghiorzo, Paola" sort="Ghiorzo, Paola" uniqKey="Ghiorzo P" first="Paola" last="Ghiorzo">Paola Ghiorzo</name>
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<affiliation wicri:level="2"><nlm:aff id="A19">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff>
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<wicri:regionArea>Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA</wicri:regionArea>
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<affiliation wicri:level="2"><nlm:aff id="A20">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea>
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<author><name sortKey="Dwyer, Terry" sort="Dwyer, Terry" uniqKey="Dwyer T" first="Terry" last="Dwyer">Terry Dwyer</name>
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<author><name sortKey="Blizzard, Leigh" sort="Blizzard, Leigh" uniqKey="Blizzard L" first="Leigh" last="Blizzard">Leigh Blizzard</name>
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<author><name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name>
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<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
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<author><name sortKey="Palmieri, Giuseppe" sort="Palmieri, Giuseppe" uniqKey="Palmieri G" first="Giuseppe" last="Palmieri">Giuseppe Palmieri</name>
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<author><name sortKey="Ribas, Gloria" sort="Ribas, Gloria" uniqKey="Ribas G" first="Gloria" last="Ribas">Gloria Ribas</name>
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<author><name sortKey="Stratigos, Alexander" sort="Stratigos, Alexander" uniqKey="Stratigos A" first="Alexander" last="Stratigos">Alexander Stratigos</name>
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<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Dermatology, University of Athens, Andreas Sygros Hospital, Athens</wicri:regionArea>
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<author><name sortKey="Council, M Laurin" sort="Council, M Laurin" uniqKey="Council M" first="M. Laurin" last="Council">M. Laurin Council</name>
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<wicri:regionArea>Division of Dermatology, Washington University School of Medicine, St. Louis, MO</wicri:regionArea>
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<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
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<author><name sortKey="Autier, Philippe" sort="Autier, Philippe" uniqKey="Autier P" first="Philippe" last="Autier">Philippe Autier</name>
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<author><name sortKey="Little, Julian" sort="Little, Julian" uniqKey="Little J" first="Julian" last="Little">Julian Little</name>
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<wicri:regionArea>Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa</wicri:regionArea>
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<author><name sortKey="Newton Bishop, Julia" sort="Newton Bishop, Julia" uniqKey="Newton Bishop J" first="Julia" last="Newton-Bishop">Julia Newton-Bishop</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Section of Epidemiology and Biostatistics, Institute of Cancer and Pathology, University of Leeds, Leeds</wicri:regionArea>
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<author><name sortKey="Sera, Francesco" sort="Sera, Francesco" uniqKey="Sera F" first="Francesco" last="Sera">Francesco Sera</name>
<affiliation wicri:level="3"><nlm:aff id="A31">UCL Institute of Child Health, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Institute of Child Health, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
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<author><name sortKey="Raimondi, Sara" sort="Raimondi, Sara" uniqKey="Raimondi S" first="Sara" last="Raimondi">Sara Raimondi</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>MC1R</italic>
 variants increased the risk of sporadic cutaneous melanoma in darker-pigmented Caucasians: a pooled-analysis from the M-SKIP project</title>
<author><name sortKey="Pasquali, Elena" sort="Pasquali, Elena" uniqKey="Pasquali E" first="Elena" last="Pasquali">Elena Pasquali</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Garcia Borr N, Jose C" sort="Garcia Borr N, Jose C" uniqKey="Garcia Borr N J" first="José C." last="García-Borr N">José C. García-Borr N</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Department of Biochemistry, Molecular Biology and Immunology, University of Murcia, Murcia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Biochemistry, Molecular Biology and Immunology, University of Murcia, Murcia</wicri:regionArea>
<wicri:noRegion>Murcia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fargnoli, Maria Concetta" sort="Fargnoli, Maria Concetta" uniqKey="Fargnoli M" first="Maria Concetta" last="Fargnoli">Maria Concetta Fargnoli</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Dermatology, University of L’Aquila, L’Aquila, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Dermatology, University of L’Aquila, L’Aquila</wicri:regionArea>
<wicri:noRegion>L’Aquila</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gandini, Sara" sort="Gandini, Sara" uniqKey="Gandini S" first="Sara" last="Gandini">Sara Gandini</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maisonneuve, Patrick" sort="Maisonneuve, Patrick" uniqKey="Maisonneuve P" first="Patrick" last="Maisonneuve">Patrick Maisonneuve</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bagnardi, Vincenzo" sort="Bagnardi, Vincenzo" uniqKey="Bagnardi V" first="Vincenzo" last="Bagnardi">Vincenzo Bagnardi</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A4">Department of Statistics and Quantitative Methods, University of Milan Bicocca, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Statistics and Quantitative Methods, University of Milan Bicocca, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Specchia, Claudia" sort="Specchia, Claudia" uniqKey="Specchia C" first="Claudia" last="Specchia">Claudia Specchia</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Molecular and Translational Medicine, University of Brescia, Brescia</wicri:regionArea>
<wicri:noRegion>Brescia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Fan" sort="Liu, Fan" uniqKey="Liu F" first="Fan" last="Liu">Fan Liu</name>
<affiliation wicri:level="3"><nlm:aff id="A6">Department of Forensic Molecular Biology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Forensic Molecular Biology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kayser, Manfred" sort="Kayser, Manfred" uniqKey="Kayser M" first="Manfred" last="Kayser">Manfred Kayser</name>
<affiliation wicri:level="3"><nlm:aff id="A6">Department of Forensic Molecular Biology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Forensic Molecular Biology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nijsten, Tamar" sort="Nijsten, Tamar" uniqKey="Nijsten T" first="Tamar" last="Nijsten">Tamar Nijsten</name>
<affiliation wicri:level="3"><nlm:aff id="A7">Department of Dermatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Dermatology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nagore, Eduardo" sort="Nagore, Eduardo" uniqKey="Nagore E" first="Eduardo" last="Nagore">Eduardo Nagore</name>
<affiliation wicri:level="1"><nlm:aff id="A8">Department of Dermatology, Instituto Valenciano de Oncologia, Valencia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Dermatology, Instituto Valenciano de Oncologia, Valencia</wicri:regionArea>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A9">Universidad Católica de Valencia, Valencia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Universidad Católica de Valencia, Valencia</wicri:regionArea>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kumar, Rajiv" sort="Kumar, Rajiv" uniqKey="Kumar R" first="Rajiv" last="Kumar">Rajiv Kumar</name>
<affiliation wicri:level="3"><nlm:aff id="A10">Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hansson, Johan" sort="Hansson, Johan" uniqKey="Hansson J" first="Johan" last="Hansson">Johan Hansson</name>
<affiliation wicri:level="3"><nlm:aff id="A11">Department of Oncology and Pathology, Cancer Center, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Oncology and Pathology, Cancer Center, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kanetsky, Peter A" sort="Kanetsky, Peter A" uniqKey="Kanetsky P" first="Peter A." last="Kanetsky">Peter A. Kanetsky</name>
<affiliation wicri:level="2"><nlm:aff id="A12">Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ghiorzo, Paola" sort="Ghiorzo, Paola" uniqKey="Ghiorzo P" first="Paola" last="Ghiorzo">Paola Ghiorzo</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa</wicri:regionArea>
<wicri:noRegion>Genoa</wicri:noRegion>
</affiliation>
<affiliation><nlm:aff id="A14">Genetics of Rare Hereditary Cancers, IRCCS AOU San Martino –IST, Genoa</nlm:aff>
<wicri:noCountry code="subfield">Genoa</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Debniak, Tadeusz" sort="Debniak, Tadeusz" uniqKey="Debniak T" first="Tadeusz" last="Debniak">Tadeusz Debniak</name>
<affiliation wicri:level="1"><nlm:aff id="A15">Department of Genetic and Pathology, Pomeranian Medical University, Polabska, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Genetic and Pathology, Pomeranian Medical University, Polabska</wicri:regionArea>
<wicri:noRegion>Polabska</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Branicki, Wojciech" sort="Branicki, Wojciech" uniqKey="Branicki W" first="Wojciech" last="Branicki">Wojciech Branicki</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Institute of Forensic Research, Krakow, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Institute of Forensic Research, Krakow</wicri:regionArea>
<wicri:noRegion>Krakow</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gruis, Nelleke A" sort="Gruis, Nelleke A" uniqKey="Gruis N" first="Nelleke A." last="Gruis">Nelleke A. Gruis</name>
<affiliation wicri:level="3"><nlm:aff id="A17">Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Dermatology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Han, Jiali" sort="Han, Jiali" uniqKey="Han J" first="Jiali" last="Han">Jiali Han</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A19">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A20">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dwyer, Terry" sort="Dwyer, Terry" uniqKey="Dwyer T" first="Terry" last="Dwyer">Terry Dwyer</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Murdoch Childrens Research Institute, Royal Children’s Hospital, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Murdoch Childrens Research Institute, Royal Children’s Hospital, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Blizzard, Leigh" sort="Blizzard, Leigh" uniqKey="Blizzard L" first="Leigh" last="Blizzard">Leigh Blizzard</name>
<affiliation wicri:level="1"><nlm:aff id="A22">Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Menzies Research Institute Tasmania, University of Tasmania, Hobart</wicri:regionArea>
<wicri:noRegion>Hobart</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Palmieri, Giuseppe" sort="Palmieri, Giuseppe" uniqKey="Palmieri G" first="Giuseppe" last="Palmieri">Giuseppe Palmieri</name>
<affiliation wicri:level="1"><nlm:aff id="A24">Unit of Cancer Genetics, Istituto di Chimica Biomolecolare, CNR, Sassari, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Unit of Cancer Genetics, Istituto di Chimica Biomolecolare, CNR, Sassari</wicri:regionArea>
<wicri:noRegion>Sassari</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ribas, Gloria" sort="Ribas, Gloria" uniqKey="Ribas G" first="Gloria" last="Ribas">Gloria Ribas</name>
<affiliation wicri:level="1"><nlm:aff id="A25">Dptd. Oncologia medica y hematologia, Fundación Investigación Clínico de Valencia Instituto de Investigación Sanitaria- INCLIVA, Valencia, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Dptd. Oncologia medica y hematologia, Fundación Investigación Clínico de Valencia Instituto de Investigación Sanitaria- INCLIVA, Valencia</wicri:regionArea>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stratigos, Alexander" sort="Stratigos, Alexander" uniqKey="Stratigos A" first="Alexander" last="Stratigos">Alexander Stratigos</name>
<affiliation wicri:level="3"><nlm:aff id="A26">Department of Dermatology, University of Athens, Andreas Sygros Hospital, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Dermatology, University of Athens, Andreas Sygros Hospital, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Council, M Laurin" sort="Council, M Laurin" uniqKey="Council M" first="M. Laurin" last="Council">M. Laurin Council</name>
<affiliation wicri:level="4"><nlm:aff id="A27">Division of Dermatology, Washington University School of Medicine, St. Louis, MO, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Dermatology, Washington University School of Medicine, St. Louis, MO</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Autier, Philippe" sort="Autier, Philippe" uniqKey="Autier P" first="Philippe" last="Autier">Philippe Autier</name>
<affiliation wicri:level="3"><nlm:aff id="A28">International Prevention Research Institute, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>International Prevention Research Institute, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Little, Julian" sort="Little, Julian" uniqKey="Little J" first="Julian" last="Little">Julian Little</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa</wicri:regionArea>
<wicri:noRegion>Ottawa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Newton Bishop, Julia" sort="Newton Bishop, Julia" uniqKey="Newton Bishop J" first="Julia" last="Newton-Bishop">Julia Newton-Bishop</name>
<affiliation wicri:level="4"><nlm:aff id="A30">Section of Epidemiology and Biostatistics, Institute of Cancer and Pathology, University of Leeds, Leeds, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Section of Epidemiology and Biostatistics, Institute of Cancer and Pathology, University of Leeds, Leeds</wicri:regionArea>
<orgName type="university">Université de Leeds</orgName>
<placeName><settlement type="city">Leeds</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Yorkshire-et-Humber</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sera, Francesco" sort="Sera, Francesco" uniqKey="Sera F" first="Francesco" last="Sera">Francesco Sera</name>
<affiliation wicri:level="3"><nlm:aff id="A31">UCL Institute of Child Health, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Institute of Child Health, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Raimondi, Sara" sort="Raimondi, Sara" uniqKey="Raimondi S" first="Sara" last="Raimondi">Sara Raimondi</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">International journal of cancer. Journal international du cancer</title>
<idno type="ISSN">0020-7136</idno>
<idno type="eISSN">1097-0215</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
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<profileDesc><textClass></textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">The <italic>MC1R</italic>
 gene is a key regulator of skin pigmentation. We aimed to evaluate the association between <italic>MC1R</italic>
 variants and the risk of sporadic cutaneous melanoma (CM) within the M-SKIP project, an international pooled-analysis on <italic>MC1R</italic>
, skin cancer and phenotypic characteristics. Data included 5,160 cases and 12,119 controls from 17 studies. We calculated a Summary Odds Ratio (SOR) for the association of each of the nine most studied <italic>MC1R</italic>
 variants and of variants combined with CM by using random-effects models. Stratified analysis by phenotypic characteristics were also performed.</p>
<p id="P2">Melanoma risk increased with presence of any of the main <italic>MC1R</italic>
 variants: the SOR for each variant ranged from 1.47 (95%CI: 1.17–1.84) for V60L to 2.74 (1.53–4.89) for D84E. Carriers of any <italic>MC1R</italic>
 variant had a 66% higher risk of developing melanoma compared to wild-type subjects (SOR; 95%CI: 1.66; 1.41–1.96), and the risk attributable to <italic>MC1R</italic>
 variants was 28%. When taking into account phenotypic characteristics, we found that <italic>MC1R</italic>
–associated melanoma risk increased only for darker-pigmented Caucasians: SOR (95%CI) was 3.14 (2.06–4.80) for subjects with no freckles, no red hair and skin type III/IV.</p>
<p id="P3">Our study documents the important role of all the main <italic>MC1R</italic>
 variants in sporadic CM and suggests that they have a direct effect on melanoma risk, independently on the phenotypic characteristics of carriers. This is of particular importance for assessing preventive strategies, which may be directed to darker-pigmented Caucasians with <italic>MC1R</italic>
 variants as well as to lightly-pigmented, fair-skinned subjects.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Canada</li>
<li>Espagne</li>
<li>France</li>
<li>Grèce</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Pologne</li>
<li>Royaume-Uni</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Attique (région)</li>
<li>Auvergne-Rhône-Alpes</li>
<li>Bade-Wurtemberg</li>
<li>District de Karlsruhe</li>
<li>Floride</li>
<li>Grand Londres</li>
<li>Hollande-Méridionale</li>
<li>Lombardie</li>
<li>Maryland</li>
<li>Massachusetts</li>
<li>Missouri (État)</li>
<li>Rhône-Alpes</li>
<li>Svealand</li>
<li>Yorkshire-et-Humber</li>
</region>
<settlement><li>Athènes</li>
<li>Heidelberg</li>
<li>Leeds</li>
<li>Leyde</li>
<li>Londres</li>
<li>Lyon</li>
<li>Milan</li>
<li>Rotterdam</li>
<li>Saint-Louis (Missouri)</li>
<li>Stockholm</li>
</settlement>
<orgName><li>Université de Leeds</li>
<li>École de médecine (Université Washington de Saint-Louis)</li>
</orgName>
</list>
<tree><country name="Italie"><region name="Lombardie"><name sortKey="Pasquali, Elena" sort="Pasquali, Elena" uniqKey="Pasquali E" first="Elena" last="Pasquali">Elena Pasquali</name>
</region>
<name sortKey="Bagnardi, Vincenzo" sort="Bagnardi, Vincenzo" uniqKey="Bagnardi V" first="Vincenzo" last="Bagnardi">Vincenzo Bagnardi</name>
<name sortKey="Bagnardi, Vincenzo" sort="Bagnardi, Vincenzo" uniqKey="Bagnardi V" first="Vincenzo" last="Bagnardi">Vincenzo Bagnardi</name>
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   |texte=   MC1R variants increased the risk of sporadic cutaneous melanoma in darker-pigmented Caucasians: a pooled-analysis from the M-SKIP project
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Serveur d'exploration sur les relations entre la France et l'Australie

MC1R variants increased the risk of sporadic cutaneous melanoma in darker-pigmented Caucasians: a pooled-analysis from the M-SKIP project

MC1R variants increased the risk of sporadic cutaneous melanoma in darker-pigmented Caucasians: a pooled-analysis from the M-SKIP project

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	Serveur d'exploration sur les relations entre la France et l'Australie
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